Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 119, Issue 9, Pages 2441-2450Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI39134
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Funding
- European Commission
- Crohn's and Colitis Foundation of America (CCFA)
- Italian Ministry of Health, the international Association for Cancer Research (AICR)
- Associazione Italiana per la Ricerca Sul Cancro (AIRC)
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DCs are specialized APCs that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs, which induce either protective immunity to infectious agents or tolerance to innocuous antigens, including food and commensal bacteria. Several subsets of mucosal DCs have been described that display unique functions, dictated in part by the local microenvironment. In this review, we summarize the distinct subtypes of DCs and their distribution in the gut; examine how DC dysfunction contributes to intestinal disease development, including inflammatory bowel disease and celiac disease; and discuss manipulation of DCs for therapy.
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