Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 118, Issue 4, Pages 1277-1290Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI34005
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI043596] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01 AI043596] Funding Source: Medline
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Enteric infections, with or without overt diarrhea, have profound effects on intestinal absorption, nutrition, and childhood development as well as on global mortality. Oral rehydration therapy has reduced the number of deaths from dehydration caused by infection with an enteric pathogen, but it has not changed the morbidity caused by such infections. This Review focuses on the interactions between enteric pathogens and human genetic determinants that alter intestinal function and inflammation and profoundly impair human health and development. We also discuss specific implications for novel approaches to interventions that are now opened by our rapidly growing molecular understanding.
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