Journal
JOURNAL OF CLINICAL IMMUNOLOGY
Volume 30, Issue 4, Pages 502-506Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10875-010-9386-5
Keywords
NLRC4; caspase 1; IL-1 beta; type III secretion; inflammation
Categories
Funding
- NIAID NIH HHS [K08 AI065878, K08 AI065878-04] Funding Source: Medline
Ask authors/readers for more resources
Cytokine production by innate immune cells is initiated by signaling downstream of pattern recognition receptors, including Toll-like receptors. A subset of cytokines, including IL-1 beta and IL-18, require post-translational proteolysis before secretion, which provides a second mechanism of regulation. This proteolysis is dependent upon caspase 1, which is activated by Nod-like receptor (NLR) signaling. NLRC4 (previously named Ipaf) activates caspase 1 in response to bacterial virulence factors including type III and IV secretion systems (T3SS and T4SS). NLRC4 recognizes T3SS/T4SS in two ways: indirectly by detecting flagellin, and directly by detecting the T3SS rod protein. Both flagellin and rod protein are unintentionally delivered to the mammalian cytosol by the bacterium through the T3SS.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available