Journal
JOURNAL OF CLINICAL IMMUNOLOGY
Volume 29, Issue 3, Pages 265-273Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10875-009-9283-y
Keywords
Myeloid dendritic cells; plasmacytoid dendritic cells; natural killer cell subsets; interleukin-12; interleukin-15; type I interferon; DC/NK cell cross-talk
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Funding
- Burroughs Wellcome Fund
- Starr Foundation
- National Cancer Institute [R01CA108609, R01CA101741]
- National Institute of Allergy and Infectious Diseases [RFP-NIH-NIAID-DAIDS-BAA-0619]
- Foundation for the National Institutes of Health
- Associazione Italiana Ricerca sul Cancro (AIRC)
- Ministero Italiano della Salute-Programma Straordinario Ricerca Oncologica
- Fondazione Banco di Sicilia
- Regione Sicilia-Ricerca Sanitaria Regionale 2007
- NATIONAL CANCER INSTITUTE [R01CA101741, R01CA108609] Funding Source: NIH RePORTER
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In recent years, it has been realized that innate lymphocytes do not act in isolation but potentiate their efficiency by interacting with each other, resulting even in the regulation of adaptive immune response. One such cross-talk exists between dendritic cells (DCs) and natural killer (NK) cells. Here, we summarize recent studies on which subsets of these two innate immune components participate in this interaction, how it influences immune responses, and to which extent similar stimuli are integrated by DCs and NK cells during innate immunity. We suggest that this cross-talk should be harnessed by activating both of these innate leucocyte populations with new adjuvant formulations for immunotherapies.
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