Journal
JOURNAL OF CLINICAL IMMUNOLOGY
Volume 29, Issue 3, Pages 282-291Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10875-008-9268-2
Keywords
ANCA; complement; histopathology; myeloperoxidase; pauci-immune; vasculitis
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Funding
- National Science Fund for Distinguished Young Scholars [30725034]
- Chinese 985 project [985-2-104113]
- Dutch Organization for Scientific research [NWO VIDI 917.66.342]
- Dutch Kidney Foundation [PC 07-2204]
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This study was to investigate the evidence for complement activation in renal biopsy specimens of patients with myeloperoxidase (MPO)-antineutrophil cytoplasmic autoantibody (ANCA)-associated pauci-immune vasculitis. Renal biopsy specimens from seven patients with MPO-ANCA positive pauci-immune necrotizing crescentic glomerulonephritis (NCGN) were used to detect the staining of membrane attack complex (MAC), C3d, C4d, mannose-binding lectin (MBL), factor B and factor P using immunohistochemistry and immunofluorescence. Renal tissue from seven patients with minimal change disease (MCD) and two normal renal tissue were used as controls. MAC, C3d, factor B and factor P could be detected in glomeruli and small blood vessels with active vasculitis of patients with pauci-immune AAV, but not or scarcely in patients with MCD and in normal renal tissue. C3d and factor B co-localized with MAC, factor P colocalized with C3d. MBL and C4d were not detected in patients with AAV. The alternative pathway of the complement system is involved in renal damage of human pauci-immune AAV.
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