Journal
JOURNAL OF CLINICAL IMMUNOLOGY
Volume 28, Issue 6, Pages 707-715Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10875-008-9248-6
Keywords
Regulatory T cells; peripheral homeostasis; controlled immune response
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Funding
- Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
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Background Various populations of regulatory cells, including Foxp3+ T-Reg, have been shown to play a central role in the maintenance of peripheral homeostasis and establishment of controlled immune responses. Objective In this review, we discuss current hypotheses and points of polemic associated with the origin, mode of action. and antigen specificity of both endogenous and induced regulatory T cells during infections.
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