Journal
JOURNAL OF CLINICAL HYPERTENSION
Volume 16, Issue 4, Pages 283-288Publisher
WILEY
DOI: 10.1111/jch.12305
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Funding
- NHLBI grant [R01 HL61753, HL79611]
- DERC Clinical Investigation Core [P30 DK57516]
- Barbara Davis Center for Childhood Diabetes [NIH-M01-RR00051]
- Colorado Heart Imaging Center in Denver, CO
- JDRF cardio-renal grant
- American Diabetes Association Junior Faculty Award [1-10-JF-50]
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Adults with type 1 diabetes have lower serum uric acid levels compared with nondiabetic adults. Little is known about the relationship between serum uric acid and blood pressure in type 1 diabetes and whether it differs from the positive relationship found in nondiabetic adults. The authors assessed the cross-sectional and longitudinal relationships over 6 years between serum uric acid and blood pressure in adults with (35 +/- 9years [n=393]) and without (38 +/- 9years [n=685]) type 1 diabetes in the Coronary Artery Calcification in Type 1 Diabetes study. In nondiabetic adults, serum uric acid was associated with systolic blood pressure in multivariable models adjusted for cardiovascular risk factors. In adults with type 1 diabetes, a negative association was observed between serum uric acid and systolic blood pressure after multivariable adjustments. A positive association was observed between serum uric acid and systolic blood pressure in nondiabetic adults. In contrast, an inverse relationship was demonstrated after multivariable adjustments in type 1 diabetes.
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