Journal
JOURNAL OF CLINICAL HYPERTENSION
Volume 13, Issue 12, Pages 873-880Publisher
WILEY
DOI: 10.1111/j.1751-7176.2011.00544.x
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Funding
- Daiichi Sankyo, Inc, Parsippany, New Jersey
- Vrinda Mahajan, PharmD, of Peloton Advantage, LLC, Parsippany, New Jersey
- Amgen Inc
- Merck Co, Inc
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This 12-week, multicenter, randomized, double-blinded, 4arm study in 440 patients with moderate to severe hypertension compared ambulatory blood pressure (ABP) responses with a triple-combination regimen (olmesartan medoxomil [OM] 40 mg, amlodipine besylate [AML] 10 mg, and hydrochlorothiazide [HCTZ] 25 mg) and its component dual-combination regimens at similar doses. At week 12, the triple combination resulted in a greater reduction in mean 24-hour systolic and diastolic blood pressure (-30.3/-18.0 mm Hg) compared with the 3 dual-combination regimens (OM 40 mg/AML 10 mg:-23.5 /-13.9, OM 40 mg/HCTZ 25 mg:-23.9 /-14.5, and AML 10 mg/HCTZ 25 mg:-18.5 mm Hg /-10.7 mm Hg; P<. 0001 each). Greater efficacy was also found during daytime and nighttime hours and during the last 6, 4, or 2 hours of the dosing interval. The authors conclude that the triple combination of OM 40 mg/AML 10 mg/HCTZ 25 mg demonstrated superior efficacy and sustained reductions in ABP compared with its dual-combination components. J Clin Hypertens (Greenwich). 2011; 13: 873880. (C) 2011 Wiley Periodicals, Inc.
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