Journal
JOURNAL OF CLINICAL GASTROENTEROLOGY
Volume 42, Issue 8, Pages S144-S147Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCG.0b013e3181662c90
Keywords
nodlike receptor; innate immunity; Crohn's disease.; ulcerative colitis
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The etiology of Crohn's disease (CD) remains poorly understood. Both mice and human studies suspected a perverse link between the microbiota and the lining, of the gut mucosa. There is now emerging evidence that suggests that Such a pathologic condition might result from an overly aggressive immune response to microbial antigens in genetically predisposed individuals. However, the multiple pathophysiologic processing steps linking environmental exposure to the clinical expression of CD area for the most part, unknown. Herein. we review evidences reflecting a general causing defect of the innate immune function of the intestinal mucosa of CD patients. which might lead to a sustained microbial-induced inflammatory response. Changing the paradigms of CD pathophysiology might lead to entirely new therapeutic approaches aiming to boost the innate immune response.
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