4.6 Article

Risk predictions for individual patients from logistic regression were visualized with bar-line charts

Journal

JOURNAL OF CLINICAL EPIDEMIOLOGY
Volume 65, Issue 3, Pages 335-342

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jclinepi.2011.06.019

Keywords

Logistic regression; Graphical representation; Risk model; Acute coronary syndromes; Diagnostic tests; Decision support systems

Funding

  1. Swedish Research Council [70297801]
  2. Crafoord Foundation [20080726]

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Objective: The interface of a computerized decision support system is crucial for its acceptance among end users. We demonstrate how combined bar line charts can be used to visualize predictions for individual patients from logistic regression models. Study Design and Setting: Data from a previous diagnostic study aiming at predicting the immediate risk of acute coronary syndrome (ACS) among 634 patients presenting to an emergency department with chest pain were used. Risk predictions from the logistic regression model were presented for four hypothetical patients in bar line charts with bars representing empirical Bayes adjusted likelihood ratios (LRs) and the line representing the estimated probability of ACS, sequentially updated from left to right after assessment of each risk factor. Results: Two patients had similar low risk for ACS but quite different risk profiles according to the bar line charts. Such differences in risk profiles could not be detected from the estimated ACS risk alone. The bar line charts also highlighted important but counteracted risk factors in cases where the overall LR was less informative (close to one). Conclusion: The proposed graphical technique conveys additional information from the logistic model that can be important for correct diagnosis and classification of patients and appropriate medical management. (C) 2012 Elsevier Inc. All rights reserved.

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