Journal
NEUROSCIENCE RESEARCH
Volume 93, Issue -, Pages 110-115Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2015.01.011
Keywords
Transgenic; Target gene KO; Genome editing; Common marmoset
Categories
Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) of Japan
Ask authors/readers for more resources
Genetically modified mice have contributed much to studies in the life sciences. In some research fields, however, mouse models are insufficient for analyzing the molecular mechanisms of pathology or as disease models. Often, genetically modified non-human primate (NHP) models are desired, as they are more similar to human physiology, morphology, and anatomy. Recent progress in studies of the reproductive biology in NHPs has enabled the introduction of exogenous genes into NHP genomes or the alteration of endogenous NHP genes. This review summarizes recent progress in the production of genetically modified NHPs, including the common marmoset, and future perspectives for realizing genetically modified NHP models for use in life sciences research. (C) 2015 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available