Journal
NEUROSCIENCE LETTERS
Volume 609, Issue -, Pages 223-228Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2015.09.034
Keywords
Profilin 1; Amyotrophic lateral sclerosis; Actin cytoskeleton
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Funding
- Motor Neuron Disease Institute Australia (MNDRIA)
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Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease and familial ALS accounts for 10% of cases. The identification of familial ALS mutations in the actin-binding protein profilin 1 directly implicates actin dynamics and regulation in the pathogenesis of ALS. The mechanism by which these mutations cause ALS is unknown. In this study we show that expression of the ALS-associated actin-binding deficient mutant of PFN1 (PFN1(C71G)) results in increased dendritic arborisation and spine formation, and cytoplasmic inclusions in cultured mouse hippocampal neurons. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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