Journal
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Volume 97, Issue 3, Pages 862-870Publisher
ENDOCRINE SOC
DOI: 10.1210/jc.2011-2684
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Funding
- NIA
- NIAMS
- National Institutes of Health (NIH)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- National Institute on Aging
- National Center for Research Resources
- NIH Roadmap for Medical Research [U01 AR45580, U01 AR45614, U01 AR45632, U01 AR45647, U01 AR45654, U01 AR45583, U01 AG18197, U01-AG027810, UL1 RR024140]
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Context: Mild abnormalities of thyroid function have been associated with both beneficial and detrimental effects on mortality. Objective: Our objective was to determine the association between continuous TSH as well as categories of thyroid function with total and cause-specific mortality in a cohort of older men. Design, Setting, and Participants: Data were analyzed from the Osteoporotic Fractures in Men (MrOS) study, a cohort of community-dwelling U. S. men aged 65 yr and older. A total of 1587 participants randomly selected for thyroid function testing were included in this analysis. TSH and free T-4 were measured at baseline, and four categories of thyroid function were defined. (subclinical hyperthyroid; euthyroid; subclinical hypothyroid TSH <10 mIU/liter; and subclinical hypothyroid, TSH >= 10 mIU/liter.) Main Outcome Measure: Total mortality, cardiovascular (CV) and cancer deaths were confirmed by review of death certificates. Results: There were 432 deaths over a mean follow-up of 8.3 yr. In fully adjusted models, there was no association between baseline TSH and any death [relative hazard (RH) = 1.01 per mIU/liter, 95% confidence interval (CI) = 0.95-1.06], CV death (RH = 1.05 per mIU/liter, 95% CI 0.96-1.15), or cancer death (RH = 0.96 per mIU/liter, 95% CI = 0.85-1.07). There was also no statistically significant association between thyroid function category and total or cause-specific mortality, but few men (n = 8) had subclinical hypothyroidism with TSH levels of 10 mIU/liter or higher. Conclusions: A single measurement of thyroid function did not predict total or cause-specific mortality in this cohort. These data support neither a beneficial nor a detrimental effect of subclinical thyroid dysfunction in older men. Summary: Subclinical thyroid dysfunction is not associated with an increased risk of all-cause or CV mortality in older men. (J Clin Endocrinol Metab 97: 862-870, 2012)
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