Journal
NEUROSCIENCE LETTERS
Volume 594, Issue -, Pages 12-16Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2015.03.042
Keywords
Physical pain; Pain empathy; Emotion regulation; Dorsolateral prefrontal cortex; Transcranial direct current stimulation; Pupil dilation
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Funding
- National Council for Scientific and Technological Development [CNPq-480891/2012-5]
- scientific initiation grant (CNPq) [160553/2013-0]
- FAPESP PhD grant (FAPESP) [2012/24696-1]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [12/24696-1] Funding Source: FAPESP
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The dorsolateral prefrontal cortex (DLPFC) is involved in the cognitive appraisal and modulation of the pain experience. In this sham-controlled study, with healthy volunteers, we used bi-hemispheric transcranial direct current stimulation (tDCS) over the DLPFC to assess emotional reactions elicited by pain observation. Left-cathodal/right-anodal tDCS decreased valence and arousal evaluations compared to other tDCS conditions. Compared to sham condition, both left-cathodal/right-anodal and left-anodal/right-cathodal tDCS decreased hostility, sadness and self-pain perception. These decreased sensations after both active tDCS suggest a common role for left and right DLPFC in personal distress modulation. However, the differences in arousal and valence evaluations point to distinct roles of lateralized DLPFC in cognitive empathy, probably through distinct emotion regulation mechanisms. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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