Journal
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Volume 93, Issue 10, Pages 3860-3869Publisher
ENDOCRINE SOC
DOI: 10.1210/jc.2007-2733
Keywords
-
Categories
Funding
- Danish National Research Foundation [02-512-55]
- University of Copenhagen
- Danish Medical Research Council [22-04-0588]
- the Lundbeck Foundation
- Danish AIDS Foundation
- Novo Nordisk Foundation
- Direktor Emil Hertz og Hustru Inger Hertz ' Fond
- Direktor Jacob Madsen og Hustru Olga Madsens Fond
- Fonden for Laegevidenskabens Fremme
- Kong Christian den Tiendes Fond
- Brodrene Hartmanns Fond
- Ragnhild Ibsens Legat
Ask authors/readers for more resources
Context: Fat redistribution, insulin resistance, and low-grade inflammation characterize HIV-infected patients with lipodystrophy. Currently, no effective therapies exist for the combined treatment of fat redistribution and insulin resistance. Objective: Our objective was to evaluate the effects of strength and endurance training on insulin sensitivity and fat distribution in HIV-infected patients with lipodystrophy. Subjects and Methods: Twenty sedentary HIV-infected men with lipodystrophy were randomly assigned to supervised strength or endurance training three times a week for 16 wk. The primary endpoints were improved peripheral insulin sensitivity (euglycemic-hyperinsulinemic clamp combined with isotope-tracer infusion) and body fat composition (dual-energy x-ay absorptiometry scan). Secondary endpoints included fasting lipids and inflammatory markers. Results: Insulin-mediated glucose uptake increased with both endurance training (55.7 +/- 11 to 63.0 +/- 11 mu mol glucose/kg lean mass center dot min, P = 0.02) and strength training (49.0 +/- 12 to 57.8 +/- 18 mu mol glucose/kg lean mass center dot min, P = 0.005), irrespective of training modality (P = 0.24). Only strength training increased total lean mass 2.1 kg [95% confidence interval (CI), 0.8-3.3], decreased total fat 3.3 kg (95% CI, -4.6 to -2.0), trunk fat 2.5 kg (95% CI, -3.5 to -1.5), and limb fat 0.75 kg (95% CI, -1.1 to -0.4). Strength training significantly decreased total and limb fat mass to a larger extent than endurance training (P < 0.05). Endurance training reduced total cholesterol, low-density lipoprotein cholesterol, free fatty acids, high-sensitivity C-reactive protein, IL-6, IL-18, and TNF-alpha and increased high-density lipoprotein cholesterol, whereas strength training decreased triglycerides, free fatty acids, and IL-18 and increased high-density lipoprotein cholesterol (P < 0.05 for all measurements). Conclusion: This study demonstrates that both strength and endurance training improve peripheral insulin sensitivity, whereas only strength training reduces total body fat in HIV-infected patients with lipodystrophy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available