4.7 Article

Bone mineral density changes during the menopause transition in a multiethnic cohort of women

Journal

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Volume 93, Issue 3, Pages 861-868

Publisher

ENDOCRINE SOC
DOI: 10.1210/jc.2007-1876

Keywords

-

Funding

  1. NIA NIH HHS [AG012505, U01 AG012531, U01 AG012546, AG012495, U01 AG012539, AG012554, AG012539, AG012553, AG012531, U01 AG012553, U01 AG012535, U01 AG012554, AG012546, AG012535, U01 AG012505, U01 AG012495] Funding Source: Medline
  2. NIDDK NIH HHS [K24 DK002759, K24 DK02759] Funding Source: Medline
  3. NINR NIH HHS [U01 NR004061, NR004061] Funding Source: Medline

Ask authors/readers for more resources

Context: Rates of bone loss across the menopause transition and factors associated with variation in menopausal bone loss are poorly understood. Objective: Our objective was to assess rates of bone loss at each stage of the transition and examine major factors that modify those rates. Design, Setting, and Participants: We conducted a longitudinal cohort study of 1902 African-American, Caucasian, Chinese, or Japanese women participating in The Study of Women's Health Across the Nation. Women were pre- or early perimenopausal at baseline. Outcome Measure: We assessed bone mineral density (BMD) of the lumbar spine and total hip across a maximum of six annual visits. Results: There was little change in BMD during the pre- or early perimenopause. BMD declined substantially in the late perimenopause, with an average loss of 0.018 and 0.010 g/cm(2) center dot yr from the spine and hip, respectively (P < 0.001 for both). In the postmenopause, rates of loss from the spine and hip were 0.022 and 0.013 g/cm(2) center dot yr, respectively (P < 0.001 for both). During the late peri- and postmenopause, bone loss was approximately 35-55% slower in women in the top vs. the bottom tertile of body weight. Apparent ethnic differences in rates of spine bone loss were largely explained by differences in body weight. Conclusions: Bone loss accelerates substantially in the late perimenopause and continues at a similar pace in the first postmenopausal years. Body weight is a major determinant of the rate of menopausal BMD loss, whereas ethnicity, per se, is not. Healthcare providers should consider this information when deciding when to screen women for osteoporosis.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available