Journal
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
Volume 54, Issue 1, Pages 31-38Publisher
JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
DOI: 10.3164/jcbn.13-33
Keywords
isoflavones; mammary tumors; ovariectomized rats; estrogen receptor
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Funding
- National Natural Science Foundation of China [81172653, 30872115, 30872114, 81202193]
- Beijing Natural Science Foundation [7122103]
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To determine the associations between isoflavone (49.72% genistin, 5.32% daidzin, 34.54% glycitin) and breast cancer risk, 150 rats were given 5 mg 7,12-dimethylbenz(a)anthracene and half of them were ovariectomized. Then normal rats and ovariectomized rats were divided Into 5 groups: control group, isoflavone high (HI), middle (MI), or low (LI) dose group consuming 100, 500, or 1000 mg isoflavones/kg diet, estrogen group (2.5 mg stilboestrol/kg diet). After 24 weeks, tumor incidences were 73% in control group, 7% In HI, 7% In MI, 27% in U. and 80% in estrogen group for normal rats; 60% in control group, 13% in HI, 7% in MI, 13% in U, and 73% in estrogen group for ovariettomized rats. Isoflavone treatment decreased tumor incidence and mean tumor number per rat and increased mean latent period compared with those in control group and estrogen group group significantly (p<0.05). The mRNA and protein expression of estrogen receptor p were significantly higher in isoflavone treatment groups than those in control group group. Moreover, isoflavone treatment significantly decreased 8-hydroxydeoxyguanosine content and Increased superoxide dismutase level in normal rats and decreased malondialdehyde concentrations in ovariectomized rats compared with control group. In conclusions, isoflavone intake significantly inhibited the development of premenopausal and postmenopausal mammary tumors.
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