Journal
JOURNAL OF CLINICAL ANESTHESIA
Volume 25, Issue 1, Pages 47-51Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jclinane.2012.07.001
Keywords
Hypothyroidism; Myxedema coma; Sunitinib; Tyrosine kinase inhibitors
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The case of a 62-year-old Caucasian woman who underwent urgent hip hemiarthroplasty for repair of a pathological fracture is reported. The patient's medical history was significant for renal cell carcinoma, cerebellar metastases, and sunitinib-induced hypothyroidism. Her intraoperative course was complicated by profound hypothermia, bradycardia, augmentation of neuromuscular blockade, delayed emergence, failure of postoperative extubation, and need for mechanical ventilation. The intensive care course was significant for hypothermia requiring forced-air warming, treatment with intravenous thyroxine (T4), and hemodynamic supportive care. (c) 2013 Elsevier Inc. All rights reserved.
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