Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 56, Issue -, Pages 26-34Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2015.06.019
Keywords
Vagus nerve stimulation; Major depressive disorder; The monoaminergic hypothesis of major; depressive disorder; The neural plasticity hypothesis of major; depressive disorder
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Funding
- Ghent Institute for Neuroscience
- Bijzonder Onderzoeksfond (BOF) from Ghent University
- Ghent University
- FWO
- BOF
- Ghent University Hospital
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Vagus nerve stimulation (VNS) is a proposed neuromodulatory treatment for medically refractory major depression. Although VNS is already used in clinical practice, the underlying mechanism of action remains unknown. The present review provides an overview of the preclinical VNS studies in view of two major hypotheses in depression research: the monoaminergic and the neural plasticity hypothesis of depression. (C) 2015 Elsevier Ltd. All rights reserved.
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