Journal
JOURNAL OF CLINICAL ANESTHESIA
Volume 20, Issue 4, Pages 276-279Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jclinane.2007.12.012
Keywords
factor VIIa; traumatic brain injury; elderly; international normalization ratio; prothrombin time; trauma
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Study objective: To examine the efficacy of recombinant factor VIIa (rVIIa) in reversing warfarin-induced coagulopathy in trauma patients presenting with intracranial hemorrhage (ICH). Design: Retrospective, cohort-controlled database review. Setting: Level 1, university-affiliated trauma center. Patients: 54 patients presenting with ICH associated with chronic warfarin therapy, 30 of whom were treated with rVIIa, and the other 24 patients treated conventionally. Measurements: We examined initial and subsequent coagulation studies (prothrombin time, international normalized ratio [INR]), blood product requirement, and clinical outcome, including time to reverse anticoagulation, duration of reversal, and subsequent mortality. Main results: Patients treated with rVIIa required significantly less plasma (4 vs 7 units) to correct their INR, and corrected in a much shorter period of time (2.4 vs 10 hrs). The duration of corrected INR after rVIIa was dose-dependent. Conclusions: Factor rVIIa provides prompt correction of the INR of dose-dependent duration in patients with ICH intracranial hemorrhage associated with warfarin use. (C) 2008 Elsevier Inc. All rights reserved.
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