Journal
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY
Volume 32, Issue 5, Pages 487-493Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/13803390903224928
Keywords
Insulin resistance; Type 2 diabetes; Cognition; Glycemic control; Quantitative insulin sensitivity check index
Categories
Funding
- [DK 064087]
- [P30-AG-08051]
- [NCRR M01 RR00096]
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000096] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK064087] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [P30AG008051] Funding Source: NIH RePORTER
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To determine whether the cognitive impairments observed in adults with type 2 diabetes mellitus (T2DM) exist in preclinical disease, we compared 38 adult participants with evidence of insulin resistance (IR) to 54 age-, gender-, and education-matched control participants on a battery of neuropsychological tests. We found that participants with IR had performance reductions in declarative memory and executive functioning. When we examined IR simultaneously with other biomedical indicators with which it co-occurs, only IR itself was associated with declarative memory, and hemoglobin A1c (HbA1c) was associated with executive functioning and working memory. We conclude that individuals with insulin resistance already demonstrate similar reductions in cognitive performance as those described in T2DM.
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