Journal
NEUROSCIENCE
Volume 284, Issue -, Pages 759-767Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2014.10.051
Keywords
Wallerian degeneration; Schwann cells; transforming growth factor-beta 1 (TGF-beta 1); rat; nerve regeneration; signal pathway
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Funding
- National Natural Science Foundation of China [81370982]
- Key Program [81130080]
- Scientific Research Foundation for Returned Scholars, Ministry of Education of China
- Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions, PAPD
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Wallerian degeneration (WD) is a process of axonal degeneration distal to the injury site followed by a robust regenerative response. It involves degeneration and regeneration which can be directly induced by nerve injury and activated by transcription factors. Although WD has been studied extensively, the precise mechanisms of transcription factors regulating WD are still elusive. In this study, we reported the effect of transforming growth factor-beta 1 (TGF-beta 1) on WD after rat sciatic nerve injury. The data showed that TGF-beta 1 may express in injured rat sciatic nerve and cultured Schwann cells (SCs). Knock down of TGF-beta 1 expressions resulted in the reduction of SC proliferation and apoptosis, up regulation of cytokines and Smad2, 4. Enhanced expression of TGF-beta 1 could promote SC proliferation and apoptosis, down regulation of cytokines and Smad2, 4. Altered expressions of TGF-beta 1 may affect Smad and AKT but not c-Jun and extracellular regulated protein kinase (ERK) pathways. Our results revealed the role of TGF-beta 1 on WD and provided the basis for the molecular mechanisms of TGF-beta 1-regulated nerve degeneration and/or regeneration. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.
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