Journal
APOPTOSIS
Volume 20, Issue 4, Pages 491-499Publisher
SPRINGER
DOI: 10.1007/s10495-015-1087-3
Keywords
Nitric oxide; S-nitrosylation; Parkinson's disease; Cell death; Apoptosis
Categories
Funding
- Hong Kong Research Grants Council Theme-based Research Scheme [T13-607/12R, HKUST10/CRF/12R, DAG12SC03S, HKUST12/CRF/13G]
Ask authors/readers for more resources
X-linked inhibitor of apoptosis (XIAP) is a protein that possesses anti-apoptotic function and dysregulation of it has been linked to a number human disease such as cancers and neurodegenerative disorders. In our previous study, we have found that nitric oxide (NO) can modulate the anti-apoptotic function of XIAP and found that this can contribute to the pathogenesis of Parkinson's disease. Specifically, we found that modification of baculoviral IAP repeat 2 of XIAP by S-nitrosylation can compromise XIAP's anti-caspase 3 and anti-apoptotic function. In this study, we report that cysteine (Cys) 90, Cys 213 and Cys 327 can be specifically S-nitrosylated by NO. We found that mutations of Cys 90 and Cys 327 affect the normal structure of XIAP. More importantly, we found that S-nitrosylation of XIAP Cys 213 impairs the anti-caspase 3 and anti-apoptotic function of XIAP that we observed in our previous study.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available