Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 968, Issue -, Pages 8-21Publisher
ELSEVIER
DOI: 10.1016/j.jchromb.2014.02.049
Keywords
Chiral pharmaceuticals; Biological matrices; Environmental matrices; Chiral stationary phases; Enantioselective chromatography
Funding
- Fundacao para a Ciencia e Tecnologia-FCT [SFRH/BD/64999/2009, SFRH/BD/86939/2012]
- FCT [FLUOROPHARMA PTDC/EBB-EBI/111699/2009, PEst-OE/EQB/LA0016/2011, CEQUIMED PEst-OE/SAU/UI4040/2011]
- National Council for Scientific and Technological Development (CNPq)
- Fundação para a Ciência e a Tecnologia [SFRH/BD/86939/2012, SFRH/BD/64999/2009] Funding Source: FCT
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This review aims to present the issues associated to enantioseparation of chiral pharmaceuticals in biological and environmental matrices using chiral stationary phases (CSP). Thus, it related some enantioselective methods in liquid chromatography (LC) and compares the importance given to chiral separation in biomedical and environmental fields. For that the most used CSP, the enantioselective chromatographic methods, their advantages and drawbacks were swiftly revised and compared. The recent advances and the limitations of chiral analytical methods in LC were also discussed. (C) 2014 Elsevier B.V. All rights reserved.
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