Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 942, Issue -, Pages 134-140Publisher
ELSEVIER
DOI: 10.1016/j.jchromb.2013.10.038
Keywords
Hollow-fiber liquid-phase microextraction; Sulfonamides; Capillary electrophoresis; Electrochemical detection; Water analysis
Funding
- Natural Science Foundation of China [21205042]
- Special Funds for the Development of Major Scientific Instruments and Equipment [2011YQ15007205]
- National Students innovative experimental project of China [1310269014]
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A hollow-fiber liquid-phase microextraction (HF-LPME) method has been developed for the preconcentration of trace sulfonamides in water samples. Six commonly used sulfonamides including sulfamethazine (SMZ), sulfamerazine (SMR), sulfadiazine (SDZ), sulfadimethoxine (SDM), sulfamethoxazole (SMX), and sulfathiazole (STZ) were determined by CE with electrochemical detection (CE-ED) after microextraction. Several factors that affect extraction efficiency, separation, and detection were investigated. Under the optimum conditions, above sulfonamide compounds could achieve baseline separation within 35 min, exhibiting a linear calibration over three orders of magnitude (r(2) >= 0.998); the obtained enrichment factors were between 121 (for SDZ) and 996 (for SDM), and the LODs were in the range of 0.033-0.44 ng/mL. The proposed HF-LPME/CE-ED method has been applied for the sensitive analyses of the real-world water samples with recoveries in the range of 75.1-109%. (C) 2013 Elsevier B.V. All rights reserved.
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