Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 931, Issue -, Pages 174-180Publisher
ELSEVIER
DOI: 10.1016/j.jchromb.2013.05.027
Keywords
Ionic liquids; Anti-hypertensives; Microextraction; Rat serum; Liquid chromatography
Funding
- Department of Science and Technology (DST)
- Council of Scientific and Industrial Research (CSIR), New Delhi, India
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A novel, simple and eco-friendly ionic liquid based dispersive liquid liquid microextraction followed by HPLC determination of anti-hypertensive drugs viz., eprosartan, valasartan, irbesartan, losartan and telmisartan in rat serum has been developed and validated. Experimental parameters influencing the extraction efficiency, nature and volume of the ionic liquid, dispenser solvent, extraction time and effect of salt were optimized. Under the optimum conditions, the extraction recoveries were between 92.85 and 98.50%. The relative standard deviations of intra-and inter-day accuracy varied between 1.9 and 9.1% (n=3). The linearity of the proposed method was 0.1-20 mu g/mL with coefficients of determination varying between 0.9979 and 0.9992. (C) 2013 Elsevier B.V. All rights reserved.
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