Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 879, Issue 1, Pages 69-74Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jchromb.2010.11.012
Keywords
Piceid; HPLC-MS-MS; In vitro metabolism; Urinary metabolite
Funding
- Natural Science Foundation of Jiangsu College University [08KJB150013]
- National Program on Key Basic Research Project [2009CB930300]
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There is considerable evidence that stilbenes provide health benefits. Trans-piceid is one of the major stilbenoid compounds in red wine and other plants. The purpose of this study is to investigate the metabolism of piceid in rats, including its conversion product by intestinal microflora in vitro and urinary metabolites. A HPLC-MS/MS method with electrospray ionization (ESI), negative ion mode and collision induced dissociation (CID), was used to elucidate the structures of the major metabolites of piceid. Three metabolites resveratrol, dihydropiceid and dihydroresveratrol were detected after incubating with gut microbiota for 5 h. Four urinary metabolites of piceid were identified as resveratrol, dihydroresveratrol monosulfate, piceid monosulfate and piceid monoglucuronide. (C) 2010 Published by Elsevier B.V.
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