Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 878, Issue 28, Pages 2817-2825Publisher
ELSEVIER
DOI: 10.1016/j.jchromb.2010.08.035
Keywords
Free fatty acid; Biomarker; Isolated post-challenge diabetes; Type 2 diabetes mellitus; Gas chromatography-mass spectrometry
Funding
- Natural Science Foundation of China [30671756]
- China's 11th Five-Year Scientific and Technical Plan [2006BAD27B05]
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Isolated post-challenge diabetes (IPD, 2h-PG >= 11.1 mmol/L and FPG < 7.0 mmol/L) is often ignored in screening for diabetes by fasting plasma glucose (FPG) levels. The aim of this study was to investigate the metabolic profiles of serum free fatty acids (FFAs) and to identify biomarkers that can be used to distinguish patients with IPD from those with type 2 diabetes mellitus (T2DM) or healthy control individuals. FFA profiles of the subjects were investigated using gas chromatography-mass spectrometry (GC-MS). Principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) were used for classification and prediction among the three groups. The predictive correct rates were 92.86% for IPD and healthy control individuals and 90.70% for T2DM and healthy control individuals, indicating that PLS-DA could satisfactorily distinguish IPD individuals from healthy controls and those with T2DM. Finally, palmitic acid, stearic acid, oleic acid, linoleic acid and a-linolenic acid were identified as potential biomarkers for distinguishing IPD from healthy control and T2DM individuals. These potential biomarkers might be helpful for diagnosis and characterization of diabetes. (C) 2010 Elsevier B.V. All rights reserved.
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