Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 878, Issue 27, Pages 2554-2562Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jchromb.2010.03.015
Keywords
Biomonitoring; Insecticide; Pyrethroid; Plasma; Organophosphorus; Carbamate; Gas chromatography-high resolution mass spectrometry
Funding
- NCRR NIH HHS [TL1 RR024158, TL1 RR024158-01] Funding Source: Medline
- NIEHS NIH HHS [R01 ES012468, R01 ES012468-01, R01 ES011158, R01 ES011158-01] Funding Source: Medline
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We have developed a gas chromatography-high resolution mass spectrometry method for measuring pyrethroid, organophosphorus, carbamate and fipronil pesticides and the synergist piperonyl butoxide in human plasma. Plasma samples were extracted using solid phase extraction and were then concentrated for injection and analysis using isotope dilution gas chromatography-high resolution mass spectrometry. The limits of detection ranged from 10 to 158 pg/mL with relative recoveries at concentrations near the LODs (e.g., 25 or 250 pg/mL) ranging from 87% to 156% (9 of the 16 compounds were within +/- 15% of 100%). The extraction recoveries ranged from 20% to 98% and the overall method relative standard deviations were typically less than 20% with some exceptions. Analytical characteristics were determined at 25,250, and 1000 pg/mL. (C) 2010 Elsevier B.V. All rights reserved.
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