Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 878, Issue 27, Pages 2659-2663Publisher
ELSEVIER
DOI: 10.1016/j.jchromb.2010.03.016
Keywords
JWH-018; Naphthalen-1-yl-(1-pentylindol-3-yl)methanone; Spice; LC/MS/MS; ESI
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The current paper describes a validated method for the detection and quantification of naphthalen-1-yl-(1-pentylindol-3-yl)methanone (JWH-018), an ingredient of a herbal mixture called Spice, by means of HPLC-ESI-MS-MS in serum. Lower limit of detection and lower limit of quantification were 0.07 and 0.21 ng/ml, respectively. In 2 subjects who consumed ca. 50 mu g/kg of JWH-018 by smoking, the active ingredient was detected by means of the described method. Thereby, the serum concentrations reached values of approx. 10 ng/ml and dropped within 3h very fast (<10% of the measured maximum concentrations). (C) 2010 Elsevier B.V. All rights reserved.
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