Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 877, Issue 10, Pages 919-926Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jchromb.2009.02.030
Keywords
On-line solid phase extraction; Mass spectrometry; High throughput; Valsartan; Candesartan
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AT1 receptor blockers are agents for the treatment of hypertension. Rapid and precise assay methods are needed to evaluate possible sub- or overdosage. A direct on-line solid phase extraction coupled to tandem mass spectrometry was developed and validated to determine valsartan (5-2000 ng/mL) or candesartan (1-200 ng/mL) in human plasma and urines. Both intra- and inter-assay accuracy and precision were in the range 89.2-111% and 0.9-16.9% RSD. Total run time was 4.5 min. This on-line clean-up-MS method Was found to be robust for the analysis of a high number of samples with unvarying performance. (C) 2009 Elsevier B.V. All rights reserved.
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