Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 877, Issue 26, Pages 2673-2695Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jchromb.2009.02.033
Keywords
Glycerophospholipids; Tandem quadrupole mass spectrometry; Ion-trap mass spectrometry; Electrospray ionization; Charge-remote fragmentation; Charge-driven fragmentation
Funding
- US Public Health Service [P41-RR-00954, P60-DK-20579]
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This review describes the use of low-energy collisionally activated dissociation (CAD) with both tandem quadrupole and ion-trap mass spectrometry toward structural characterization of glycerophospholipids (GPLs), including classes of glycerophosphocholine, glycerophosphoethanolamine, glycerophosphoserine, glycerophosphoglycerol glycerophosphoinositol and glycerophosphatidic acid, as well as their lyso-, plasmanyl, and plasmenylphospholipid subclasses. The mechanisms underlying the fragmentation processes leading to structural characterization of GPLs in various ion forms desorbed by electrospray ionization in the positive-ion and negative-ion modes are also discussed. The tandem mass spectrometric approaches afford the identification of the polar head group, the fatty acid substituents and the location of the radyl groups on the glycerol backbone of all the GPLs. (C) 2009 Elsevier B.V. All rights reserved.
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