Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 877, Issue 4, Pages 375-381Publisher
ELSEVIER
DOI: 10.1016/j.jchromb.2008.12.030
Keywords
Organophosphorus flame retardants; OPFR; Dialkyl phosphate metabolites; BCEP; DPP; DmCP; DpCP; TCEP; TPP; TCP
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Organophosphorus flame retardants (OPFR), phosphorus triesters, are widely used chemicals with a high share of the worldwide flame retardant market. In animal experiments, dialkyl- and diarylphosphates are the main metabolites of OPFR. Therefore we elaborated a GC-MS/MS-method for the detection of OPFR-metabolites in human urine after solid phase extraction and derivatization with pentafluorobenzylbromide. The limits of detection range from 0.1 to 1 mu g/l. Interday imprecision Were 2-8%. The applicability of the method is shown by determination of the internal burden of 30 persons of the German general population. OPFR-metabolite concentrations range from
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