Review of statistical methodologies used to compare (bio)assays

At any phase of the development of a drug or a vaccine, scientists need to compare different (bio)assays. The objective of this paper is to review different statistical methodologies that could be used to assess the equivalence between methods. Depending on the objective (average or individual equivalence), depending on the design, several approaches are detailed: two one-sided t-tests, concordance correlation coefficient. limits of agreement, tolerance intervals and probabilistic approach. (C) 2009 Elsevier B.V. All rights reserved.