Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 877, Issue 11-12, Pages 1185-1192Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jchromb.2009.03.009
Keywords
Tobacco-specific N-nitrosamines (TSNA); 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK); 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL); N-nitrosonornicotine (NNN); N-nitrosoanabasine (NAB); N-nitrosoanatabine (NAT); Biological monitoring; Tobacco smoking; Human urine
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Tobacco-specific N-nitrosamines (TSNA) include 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), N-nitrosonornicotine (NNN), N-nitrosoanabasine (NAB) and N-nitrosoanatabine (NAT). TSNA are suggested to play an important role in tobacco smoke carcinogenesis. We have developed and validated an LC-MS/MS method for the determination of total (free and conjugated)TSNA in human urine. The limits of detection (LOD) were 2.0, 0.8, 1.1 and 0.7 pg/ml for NNAL, NNN, NAB and NAT, respectively. Smokers were found to have significantly higher levels of TSNA in their urine than nonsmokers. In conclusion, the newly developed method is suitable for assessing the tobacco use-related exposure to NNK, NNN, NAB and NAT. (C) 2009 Elsevier B.V. All rights reserved.
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