Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 877, Issue 26, Pages 2822-2829Publisher
ELSEVIER
DOI: 10.1016/j.jchromb.2008.11.033
Keywords
Lipids; Direct profiling; Tissue; MALDI; MS/MS
Funding
- National Institute on Drug Abuse
- NIH
- Office of National Drug Control Policy (ONDCP)
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Advances in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) have allowed for the direct analysis of biological molecules from tissue. Although most of the early studies of direct tissue profiling by MALDI-TOFMS have focused on proteins and peptides, analysis of lipids has increased dramatically in recent years. This review gives an overview of the factors to consider when analyzing lipids directly from tissue and some recent examples of the use of MALDI-TOFMS for the direct profiling of lipids in tissue. Published by Elsevier B.V.
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