Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 877, Issue 8-9, Pages 833-836Publisher
ELSEVIER
DOI: 10.1016/j.jchromb.2009.01.041
Keywords
Capillary zone electrophoresis; Local anaesthetics; Opium alkaloids; Urine samples
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The present study describes the simultaneous determination of four drugs, two local anaesthetics (lidocaine and bupivacaine) and two opium alkaloids (noscapine and papaverine) by capillary zone electrophoresis (CZE) with solid-phase extraction (SPE) procedure using Oasis HLB cartridges. Their recoveries ranged from 81 to 107% at the target concentrations of 2.0, 5.0 and 8.0 mu g mL(-1) in spiked urine samples. Coefficients of variation of the recoveries ranged from 2.1 to 11.3% at these concentrations. The quantitation limits of the method were approximately 300 ng mL(-1) for the different compounds studied. The assay is very specific for these compounds and requires a short sample preparation procedure Prior to the electrophoretic analysis. (C) 2009 Elsevier B.V. All rights reserved.
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