Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 875, Issue 1, Pages 317-322Publisher
ELSEVIER
DOI: 10.1016/j.jchromb.2008.05.019
Keywords
Capillary electrochromatography; Cellulose tris(3,5-dimethylphenylcarbamate); Covalently bonded chiral stationary phase; Enantioseparation; Silica monolithic column
Funding
- Natural Science Foundation of China [20475054]
- CAS [KGCX2-SW-213-04]
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A chiral capillary monolithic column for capillary electrochromatography (CEC) was prepared by covalent bonding of cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC) on the silica monolithic matrix within the confine of a 50-mu m i.d. bare fused silica capillary. Several pairs of enantiomers including neutral and basic analytes were baseline resolved on the newly prepared chiral capillary monolithic column in CEC with aqueous mobile phases. Fast enantioseparation was achieved due to the favorable dynamic properties of silica monolith. The covalent bonding of CDMPC as the chiral stationary phase for CEC also enabled the use of THF in mobile phase for enantioseparation of prazquantel by overcoming the incompatibility of THF and the physically coated CDMPC on a column. (c) 2008 Published by Elsevier B.V.
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