Journal
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
Volume 871, Issue 2, Pages 143-163Publisher
ELSEVIER
DOI: 10.1016/j.jchromb.2008.07.004
Keywords
metabolomics; metabonomics; identification; mass spectrometry
Funding
- EW
- CEA (Commissariat a l'Energie Atomique)
- Technologie Servier
- FSR (Fonds Speciaux de Recherche, Universite catholique de Louvain)
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The metabolome is characterized by a large number of molecules exhibiting a high diversity of chemical structures and abundances, requiring complementary analytical platforms to reach its extensive Coverage. Among them, atmospheric pressure ionization mass spectrometry (API-MS)-based technologies, and especially those using electrospray ionization are now very popular. In this context. this review deals with strengths, limitations and future trends ill the identification of signals highlighted by API-MS-based metabolomics. It covers the identification process from the determination of the molecular mass and/or its elemental composition to the confirmation of structural hypotheses. Furthermore, some tools that were developed ill Order to address the MS signal redundancy and some approaches that could facilitate identification by improving the Visualization and organization of complex data sets are also reported and discussed. (C) 2008 Elsevier B.V. All rights reserved.
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