Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1334, Issue -, Pages 44-54Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2014.01.075
Keywords
Liquid chromatography; beta(2)-Amino acids; Quinine-and quinidine-based chiral; zwitterionic ion-exchanger selectors; Temperature dependence of enantioseparation
Funding
- Hungarian National Science Foundation [OM K 108847, TeT-10-1-2011-0055]
- Pilar Franco (Chiral Technologies Europe)
- TAMOP [4.2.4. A/2-11-1-2012-0001]
- European Union
- European Social Fund
- European Regional Development Fund under the Operational Program Innovative Economy
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The enantiomers of sixteen unusual beta(2)-amino acids were directly separated on chiral stationary phases containing quinine- or quinidine-based zwitterionic selectors. The effects of the mobile phase composition, the structure of the analyte and temperature on the separations were investigated. Experiments were performed at constant mobile phase compositions in the temperature range 5 to 55 C in order to study the effects of temperature, and thermodynamic parameters were estimated from plots of Ink or In a vs. 1/T. Some mechanistic aspects of the chiral recognition process are discussed with respect to the structures of the analytes. It was found that the enantiomeric separations were in most cases enthalpically driven, but entropically driven separation was also observed. The sequence of elution of the enantiomers was determined in some cases. (c) 2014 Elsevier B.V. All rights reserved.
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