Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1343, Issue -, Pages 101-108Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2014.03.061
Keywords
Bilayer cyclodextrin; Surface-up; Click chemistry; Enantioseparation; Adsorption
Funding
- National Natural Science Foundation of China [21205086]
- Tianjin Research Program of Application Foundation and Advanced Technology [13JCQNJC05400]
- grant-Singapore GSK-EDB Trust Fund [M4060889]
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A new generation of triazole-bridged bilayer cyclodextrins (CDs) chiral stationary phase (CSP) material was constructed via a surface-up 'click' approach. The synergistic effect of the tandem-inverted duplex CDs was evidenced by the superior enantioresolution ability toward selected chiral compounds and the enhanced adsorption ability toward hesperetin. The enantioselectivities of dansyl amino acids and aryl carboxylic acids were promoted by 10-20%, while the resolutions of some aryl carboxylic acids were significantly increased from 0 to 3.5 and beyond. Adsorption experiments of hesperetin reveal that the binding ability of the target bilayer CDCSP is nearly 23 times than that of the single layer CDCSP. The current work provides a simple and practical approach to design and synthesize novel functional materials with cooperative CD dimers on surfaces. (C) 2014 Elsevier B.V. All rights reserved.
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