Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1362, Issue -, Pages 110-118Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2014.08.030
Keywords
QuEChERS; Q-Orbitrap; Milk and milk products; Phthalates
Funding
- project of General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China [2012104002, 2013IK198]
- Graduate Innovation Fund of Shaanxi University of Science and Technology
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A new analytical method was developed and validated for simultaneous analysis of 27 phthalates in milk and milk products. Response surface methodology was employed to optimize a quick, easy, cheap, effective, rugged, and safe (QuEChERS) sample preparation method. Ultrahigh-performance liquid chromatography and electrospray ionization quadrupole Orbitrap high-resolution mass spectrometry (UHPLC/ESI Q-Orbitrap) was used for the separation and detection of all the analytes. The method was validated by taking into consideration the guidelines specified in Commission Decision 2002/657/EC and 2007/19/EC. The extraction recoveries were in a range of 90.7% to 104.6%, with coefficient of variation <5.6%. The 27 compounds behave dynamic range in the 0.1-1000 mu g kg(-1) concentration, with correlation coefficient >0.99. The limits of detection for the analytes are in the range 0.32-2.6 mu g kg(-1). This method has been successfully applied on screening of phthalates in 96 commercial milk and milk product samples. (C) 2014 Elsevier B.V. All rights reserved.
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