Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1238, Issue -, Pages 68-76Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2012.03.035
Keywords
Counter-current chromatography; Centrifugal partition chromatography; Solvent system selection; Screening of two-phase liquid systems; COSMO-RS
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The selection of the mobile and the stationary phase in support-free liquid-liquid chromatography (centrifugal partition chromatography and counter-current chromatography) is equivalent to a selection of a biphasic liquid system and its global composition. There is an immense number of choices of biphasic liquid systems. On one hand what makes this technique extremely versatile, on the other hand turns the selection of the appropriate system for a particular separation problem into a challenging and demanding task. In this work a systematic procedure for the selection of biphasic liquid systems for preparative scale separations is presented. The procedure is adaptable to the production scale requirements including production cost and safety. The experimental effort of different stages of the selection procedure is minimized by using a fully predictive method, the conductor-like screening model for real solvents (COSMO-RS). The COSMO-RS is used to assess properties relevant for the selection of a biphasic liquid system, such as the solute solubility and the partition coefficient. (C) 2012 Elsevier B.V. All rights reserved.
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