4.6 Article

Simultaneous determination of thirty non-steroidal anti-inflammatory drug residues in swine muscle by ultra-high-performance liquid chromatography with tandem mass spectrometry

Journal

JOURNAL OF CHROMATOGRAPHY A
Volume 1219, Issue -, Pages 104-113

Publisher

ELSEVIER
DOI: 10.1016/j.chroma.2011.11.009

Keywords

Ultra-high-performance liquid chromatography; Tandem mass spectrometry; Non-steroidal anti-inflammatory drugs; Multi-residue analysis; Swine muscle

Funding

  1. General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China [2009IK314]
  2. Chinese Academy of Inspection and Quarantine [2008JK001, 2008JK002]

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An ultra-high-performance liquid chromatography with tandem mass spectrometric detection (UHPLC-MS/MS) method was established for the simultaneous determination of residues of thirty non-steroidal anti-inflammatory drugs (NSAIDs) in swine muscle. The samples were extracted with acetonitrile and phosphoric acid. The extracts were defatted with n-hexane, and then purified by HLB solid-phase extraction cartridge. Analysis was carried out on UHPLC-ESI-MS/MS working with multiple reaction monitoring mode with polarity switching. Limits of detection were between 0.4 mu g/kg and 2.0 mu g/kg, and limits of quantification were between 1.0 mu g/kg and 5.0 mu g/kg. The recoveries of NSAIDs were between 61.7% and 125.7% at spiked levels of 1.0-500 mu g/kg. The repeatability was less than 8% and the within-laboratory reproducibility was not more than 12.3%. The method was reliable, convenient and sensitive. (C) 2011 Elsevier B.V. All rights reserved.

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