Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1249, Issue -, Pages 62-82Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2012.05.049
Keywords
System selectivity cube; Hydrophobic subtraction model; Column selectivity; Reversed phase; Orthogonal separation; Snyder-Dolan model
Funding
- American Chemical Society Petroleum Research Fund
- Drake University Science Collaborative Institute
- Camille and Henry Dreyfus Faculty Start-Up Award
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We have compared over 500 RPLC columns characterized by the hydrophobic subtraction model using the system selectivity cube (SSC). We have shown numerous differences in column selectivity even among columns in the same class (e.g., alkyl-silica, cyan, or embedded polar groups). We also illustrate the utility of our method for selecting alternative columns with different selectivities for problematic separations and for selecting orthogonal columns for use in two-dimensional separations. The system selectivity cube offers a visual way to easily compare many columns simultaneously and select those columns offering the desired selectivity. (C) 2012 Elsevier B.V. All rights reserved.
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