Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1246, Issue -, Pages 69-75Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2012.02.038
Keywords
LC x LC; Comprehensive two-dimensional liquid chromatography; Peak capacity; Peak distribution; Orthogonality
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In LC x LC the peak capacity (2D)n and the orthogonality O are often used as parameters of resolving power. Unfortunately, these parameters are not easily accessible from chromatograms. In this work we will present a novel method, based on the description as vectors of experimentally easily accessible data. This approach makes it possible to calculate separation space (peak distribution) in parallelograms and other more complex geometric patterns by describing a two dimensional area by vectors. The calculated separation space allows a comparison between several column combinations and is a useful tool in Optimization of LC x LC analysis. (C) 2012 Elsevier B.V. All rights reserved.
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