Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1240, Issue -, Pages 1-20Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2012.03.038
Keywords
Two-dimensional chromatography; 2D-LC; LCCC; Synthetic polymers; Biopolymers; Biocompatible polymers
Funding
- Dutch Polymer Institute (DPI) [612]
- Thuringer Ministerium fur Bildung, Wissenschaft und Kultur [B515-07008, B715-08011]
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Synthetic polymers as well as biopolymers reveal complex structures, such as variations in functionality, chain length and architecture. Therefore, combinations of different chromatographic techniques are a prerequisite for a detailed characterization. One possible approach is the combination of high performance liquid chromatography at critical conditions (LCCC) and size-exclusion chromatography, also named as two-dimensional chromatography, which allows the separation of the polymers according to different properties, like molar mass, chemical composition or functionality. In addition, LCCC hyphenated with different mass spectrometry techniques, e.g. MALDI-TOF or ESI-TOF, leads to additional information about molecular details of the polymeric structure. We summarize in this article the recent developments in two-dimensional chromatography of synthetic polymers and biopolymers since 2005. (C) 2012 Elsevier B.V. All rights reserved.
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