Fast liquid chromatography-tandem mass spectrometry for the analysis of bisphenol A-diglycidyl ether, bisphenol F-diglycidyl ether and their derivatives in canned food and beverages

In this work a fast liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method using a C18 Fused Core (TM) column, was developed for the simultaneous analysis of bisphenol A diglycidyl ether (BADGE), bisphenol A (2,3-dihydroxypropyl) glycidyl ether (BADGE center dot H2O), bisphenol A bis(2,3-dihydroxypropyl) ether (BADGE center dot 2H(2)O), bisphenol A (3-chloro-2-hydroxypropyl) glycidyl ether (BADGE center dot HCI), bisphenol A bis(3-chloro-2-hydroxypropyl) ether (BADGE center dot 2HCl) and bisphenol A (3-chloro-2-hydroxypropyl)(2,3-dihydroxypropyl ether) (BADGE center dot HCI center dot H2O) and bisphenol F diglycidyl ether (BFDGE), bisphenol F bis(2,3-dihydroxypropyl) ether (BFDGE center dot 2H(2)O), bisphenol F bis(3-chloro2-hydroxypropyl) ether (BFDGE center dot 2HCl). The LC method was coupled with a triple quadrupole mass spectrometer, using an ESI source in positive mode and using the [M+NH4](+) adduct as precursor ion for tandem mass spectrometry experiments. The method developed was applied to the determination of these compounds in canned soft drinks and canned food. OASIS HLB solid phase extraction (SPE) cartridges were used for the analysis of soft drinks, while solid canned food was extracted with ethyl acetate. Method limits of quantitation ranged from 0.13 mu g L-1 to 1.6 mu g L-1 in soft drinks and 1.0 mu g kg(-1) to 4.0 mu g kg(-1) in food samples. BADGE center dot 2H(2)O was detected in all the analyzed samples, while other BADGEs such as BADGE center dot H2O, BADGE center dot HCl center dot H2O, BADGE center dot HCl and BADGE center dot 2HCl were also detected in canned foods. (C) 2011 Elsevier B.V. All rights reserved.