Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1218, Issue 49, Pages 8813-8825Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2011.10.009
Keywords
Mixed-mode chromatography; Stationary phase; Molecular interactions; Stoichiometric displacement theory; Biopolymer
Funding
- Foundation of Provincial Key Laboratory of Modern Separation Science [0505JS60]
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Mixed-mode chromatography is a type of chromatography in which a chromatographic stationary phase interacts with solutes through more than one interaction mode. This technique has been growing rapidly because of its advantages over conventional chromatography, such as its high resolution, high selectivity, high sample loading, high speed, and the ability to replace two conventionally corresponding columns in certain circumstances. In this work, some aspects of the development of mixed-mode chromatography are reviewed, such as stationary phase preparation, combinations of various separation modes, separation mechanisms, typical applications to biopolymers and peptides, and future prospects. (C) 2011 Elsevier B.V. All rights reserved.
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