Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1218, Issue 35, Pages 5920-5938Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2011.06.052
Keywords
HILIC; Retention; Selectivity; Polar stationary phase; Column temperature; Salt concentration
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More and more polar stationary phases have become available for the separation of small polar compounds in the past decade as hydrophilic interaction chromatography (HILIC) continues to find applications in new fields (e.g., metabolomics and proteomics). Bare silica phases remain popular, especially in the bio-analytical area. A wide range of functional groups (e.g., amino, amide, diol, sulfobetaine, and triazole) have been employed as polar stationary phases for HILIC separation. This review provides a survey of the popular stationary phases commercially available and discusses the retention and selectivity characteristics of the polar stationary phases in HILIC. The purpose of the review is not to provide a comprehensive overview of literature reports, but rather focuses on findings that demonstrate retention and selectivity of the polar stationary phases in HILIC. (C) 2011 Elsevier B.V. All rights reserved.
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